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Why Depression in Asthma May Differ from Typical Depression
A new study from Hiroshima University in Japan suggests that depression in people with asthma may work differently inside the body than primary depression.
Researchers found that adults with asthma who had symptoms of depression showed higher levels of BDNF, a protein linked to brain health. This finding is surprising because people with major depressive disorder often show lower levels of BDNF.
What BDNF Does
BDNF (brain-derived neurotrophic factor) helps protect brain cells and supports learning and memory. In typical depression, levels often drop. However, asthma appears to change this pattern.
BDNF is also active in the lungs, especially during inflammation. It can affect nerves in the airways and make asthma symptoms worse. This includes coughing, wheezing, or breathing difficulties.
How the Study Worked
Scientists evaluated 140 adults with asthma. They measured BDNF levels, checked symptoms of depression and anxiety, and tracked physical activity using small wearable devices. This helped them see how movement, mood, and asthma severity connect.
Key Findings
The study found that:
• people with asthma and depression had higher BDNF levels
• more severe asthma often meant higher BDNF levels
• less physical activity linked to stronger feelings of depression
These results suggest that inflammation and reduced movement may play major roles in asthma-related depression.
Why It Matters
The findings may change how doctors think about treating asthma and mental health. At the moment, both conditions are treated separately. However, combining care may lead to better outcomes for patients.
Researchers plan to run longer studies to learn how inflammation, BDNF, and physical activity interact over time. They also want to test whether exercise or asthma treatments can improve mood as well as breathing.
Bottom Line
Depression in asthma may not follow the same biological pattern as primary depression. Because of this, it may require different treatment strategies and closer attention to inflammation and physical activity.
